Animal Models for Studying Female Genital Tract Infection with Chlamydia trachomatis
نویسندگان
چکیده
منابع مشابه
Animal models for studying female genital tract infection with Chlamydia trachomatis.
Chlamydia trachomatis is a Gram-negative obligate intracellular bacterial pathogen. It is the leading cause of bacterial sexually transmitted disease in the world, with more than 100 million new cases of genital tract infections with C. trachomatis occurring each year. Animal models are indispensable for the study of C. trachomatis infections and the development and evaluation of candidate vacc...
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The purpose of the present study was to evaluate pigs as a large-animal model for female genital infection with two Chlamydia trachomatis human serovar E strains. Sixteen-week-old specific-pathogen-free female pigs (gilts) were intravaginally infected with the trachoma type E reference strain Bour or the urogenital serovar E strain 468. Several conclusions can be drawn from our findings on the ...
متن کاملGlycogen assay for diagnosis of female genital Chlamydia trachomatis infection.
Chlamydia trachomatis can synthesize glycogen at various stages in its developmental cycle. The glycogen content of female genital epithelial cells was detected by anthrone, and the results were compared with those from PCR. A total of 320 cervical samples were examined. Of 92 specimens that were positive by PCR, 78 were positive and 14 were negative by the glycogen assay. Of 228 specimens that...
متن کاملPersistent "silent" Chlamydia trachomatis female genital tract infections.
Chlamydia trachomatis; infection; heat shock proteins hronic chlamydial infections have been documented in numerous works 1,z as silently evolving diseases. Evidence of resistance to antibiotic therapy, as demonstrated by positive cultures long after treatment in infertile women, 3,4 as well as positive chlamydial antigens or nucleic acids in culture-negative pelvic samples of infertile women s...
متن کاملEfficacy of an Immune Modulator in Experimental Chlamydia trachomatis Infection of the Female Genital Tract
OBJECTIVE The aim of this study was to determine if vaginal application of the immune response modifier imiquimod (Aldara cream, 3M Pharmaceuticals, St Paul, Minn) would alter the course and/or outcome of female genital tract infection with a human isolate of Chlamydia trachomatis in a murine model. METHODS Groups of CF-1 mice were treated with Aldara on three different schedules: (1) ongoing...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 2013
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.00357-13